She is the Queen of the Karura clan and the Southern Bushinshou. She has a little sister, Karyobinga, whom she cares about very much, and does not want her in danger. That was the only reason she stayed loyal to Taishakuten; she wanted to protect Karyobinga. But after Taishakuten killed Karyobinga and fed the body to his pet beasts, it drove Karura-ou mad. She attacked Taishakuten, but the Southern General Zouchou-ten blocked the attack for Taishakuten and asked him to not kill Karura-ou, but instead, just remove her title. Taishakuten agreed to it, but the fact remains that Karura-ou had gone against him, so the people of the Karura clan could still be killed. To ensure the safety of her clan, Karura-ou faked her death, pretending to have committed suicide. (Since the Queen was "dead", the clan could not be punished anymore.) She secretly joins up with Yasha, Ashura, and the rest of the group. Everyone of the Karura clan has a bird who is linked to them, kind of like a Familiar. Karura-ou's bird is Garuda, which is also her weapon. She can use her own energy as attacks as well as summoning Garuda to attack the enemy.
She is killed by Taishakuten in a one-on-one fight. She dies sorry that she couldn't avenge her sister's murder but is glad to go be with her again, as her sister was seen collecting Karura-ou’s soul.
(Source: Source: Nishi's RG Veda Gallery, RG Veda Wikia)