Sasame is a young kunoichi of the Fūma clan.
While searching for her cousin, Arashi, Sasame approaches Kamikiri, Kagerō, and Jigumo for help. She takes part in a fake battle with them to win the trust of Naruto, Sakura, and Jiraiya, who tend to her after rescuing her. While she has her clothes off inside a room, Naruto is being shown attempting to peek at the nude Sasame until Sakura notices him and hits him on the head. After they come out, Naruto is surpised and wondering who Sasame is, at which time Sakura informs Naruto that Sasame and the mystery ninja they picked up are the same person. Ironically, this causes Naruto to realize that he accidently groped Sasame when he rescued her before. At that time Sakura strikes him on the head again for daydreaming something perverted and the group is attacked by the previous ninja group, who turn out to be members of the Fūma. After with fighting the other Fūma again, she leads the three to Orochimaru's lair. When she did locate the lair, she ended up in a rope trap where she persuaded the three to let her help in exchange for seeing Arashi. Sasame planned on giving Naruto, Jiraiya and Sakura tea with a drug to make them fall asleep, and handing them over to Kamikiri in exchange for being allowed to see Arashi. However, the plan failed when Kamikiri revealed that he wanted to kill them instead of capturing them, and Sasame was knocked unconscious when she protested against that. Naruto, Sakura, and Jiraiya revealed that they had only pretended to go along with her plan, and defeated the three Fūma ninja. Almost as soon as she regained consciousness, Sasame tried to commit suicide over having failed, but Jiraiya stopped her and convinced her to show them to the hideout. Despite being ordered to stay behind, Sasame follows Naruto into the hideout and saves him from a slowly flooding room by opening the trapdoor, allowing him to catch up with Sakura. She later saves Naruto from Kagerō (who was disguised as Kabuto Yakushi) by giving Sakura a seal that will free them from her attack. When she met Arashi, she saw what had become of her cousin she decided to help Naruto and Sakura in defeating him. After the incident, she decided to join forces with Hanzaki and the remaining members of the Fūma clan to rebuild the clan's former glory.