A member of the "Pleiades Six Stars", the battle maid squad of the Great Tomb of Nazarick. She serves as the role of battle cleric and focuses on healing magic. In terms of combat ability, she possesses the highest physical defense and resistances among the Pleiades, and has balanced stats overall. Being a werewolf, she is weak to silver weapons, but is blessed with resistance against other metals.
Her appearance is that of a brown-skinned beauty with amber-colored eyes, and red hair which she ties in two long braids. She wears a maid uniform with short sleeves and long black gloves, white stockings, and a skirt that has a long slit on its left side. She is usually seen carrying her signature weapon slung across her back, a menacing black and silver scepter which looks like and oversized religious symbol, the Crosier.
Lupusregina boasts a very sociable and outgoing personality, and seems very friendly, even towards humans, a race considered unworthy of respect by other beings of Nazarick. For example, she adds "-chan" to the other maid's names, and often likes teasing Enri with lewd jokes. The Homunculus Maids (the ordinary maids of Nazarick) are convinced she's the friendliest of the Pleiades and even believe that being approached by her can be a sign of good fortune. However, her fellow battle-maid Yuri Alpha has commented that Lupusregina's friendliness is merely a facade, and that in reality she can be as brutal and sadistic as Solution.
She likes startling people by using her "Complete Invisibility" spell and appearing behind them unnoticed.